Collect. Czech. Chem. Commun.
2011, 76, 193-205
https://doi.org/10.1135/cccc2010144
Published online 2011-02-21 10:05:22
Spectrophotometric determination of atorvastatin and amlodipine by H-point standard addition method with simultaneous addition of both analytes in nonaqueous solution
Farhad Ahmadi* and Ghordoie-Milan Ramin
Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 67145-1673, Islamic Republic of Iran
Abstract
H-point standard addition method(HPSAM) with simultaneous addition of both analytes in nonaqueous solution was applied for determination of Atorvastatin (AT) and Amlodipine (AML). The results showed that simultaneous determination could be performed with the ratio 0.16 to 4.3 of AT–AML. The corresponding values of LOD were obtained for AT and AML 1.2 × 10–6 and 9 × 10–7 mol l–1, respectively, and the corresponding values of LOQ were obtained for AT and AML 4 × 10–6 and 3 × 10–6 mol l–1, respectively. Underworking conditions, the proposed method was successfully applied for simultaneous determination of AT and AML in several synthetic mixtures and Amostatine tablets.
Keywords: Analytical methods; Computational chemistry; Medicinal chemistry; H-Point standard addition method; Atorvastatin; Amlodipine; Amostatine; HPLC.
References: 38 live references.
