Collect. Czech. Chem. Commun. 2011, 76, 1307-1315
Published online 2011-10-30 22:40:24

Solvent-free, one-pot synthesis of 2,4,6-triarylpyridines using trichloroisocyanuric acid or N-bromosuccinimide as a novel and neutral catalyst

Behrooz Maleki*, Hafezeh Salehabadi, Zeinalabedin Sepehr and Mina Kermanian

Department of Chemistry, Sabzevar Tarbiat Moallem University, 397 Sabzevar, Iran


A simple and benign protocol has been explored for the preparation of 2,4,6-triarylpyridines by a one-pot reaction between aryl aldehydes, enolizable ketones and ammonium acetate in the presence of N-bromosuccinimide or trichloroisocyanuric acid as green and neutral catalysts. The reactions proceed smoothly at 130 °C under solvent-free conditions to provide 2,4,6-triarylpyridines in good yields.

Keywords: 2,4,6-Triarylpyridines; Aldehydes; Ketones; Ammonium acetate; N-Bromosuccinimide; Trichloroisocyanuric acid; Green chemistry.

References: 50 live references.