Collect. Czech. Chem. Commun.
2011, 76, 65-74
https://doi.org/10.1135/cccc2010105
Published online 2011-01-05 10:47:19
Steroid and bile acids amide conjugates with D-glucosamine
Zdena Nováková, Jana Tomanová, Lucie Štěrbová and Pavel Drašar*
Institute of Chemical Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
Abstract
New type of amide conjugates of steroid and bile acids with D-glucosamine 1 and 2 were prepared. Title compounds are prepared via acid chloride or using N-[({[(1E)-1-cyano-2-ethoxy-2-oxoethylidene]amino}oxy)(dimethylamino)methylidene]-N-methylmethanaminium tetrafluoroborate as condensation agent. They were examined for gelation properties with negative results. Per-O-acetylated D-glucosamine hydrochloride was prepared in one step procedure from D-glucosamine hydrochloride by acetylation in a mixture of acetyl chloride and acetic acid.
Keywords: Steroids; Carbohydrates; Amides; Bile acids.
References: 28 live references.
