Collect. Czech. Chem. Commun. 2010, 75, 995-1022
Published online 2010-09-27 08:46:00

New developments in the medicinal chemistry of carboranes

Rashmirekha Satapathya, Barada Prasanna Dasha, John A. Maguireb,* and Narayan S. Hosmanea,*

a Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115-2862, USA
b Department of Chemistry, Southern Methodist University, Dallas, Texas 75275-0314, USA


The advancements in the synthetic chemistry of carboranes and metallacarboranes have given rise to diversified uses in medicinal chemistry, resulting in many new medical applications. An overview of the medicinal chemistry of carboranes is presented emphasizing the use of nanoparticles, dendrimers, porphyrins and carbohydrates as boron carriers. A review with 80 references.

Keywords: Carboranes; Metallacarboranes; Medicinal chemistry; Nanoparticles; Dendrimers; Porphyrins; Carbohydrates.

References: 168 live references.