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Collect. Czech. Chem. Commun. 2010, 75, 767-784
Published online 2010-08-02 23:32:42

Cholesterol solubilization by oxo derivatives of selected bile acids and their membranotoxicity

Mihalj Poša* and Zita Farkaš

Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljka 3, 21000 Novi Sad, Serbia

Crossref Cited-by Linking

  • Poša Mihalj: Self-Association of the Anion of 7-Oxodeoxycholic Acid (Bile Salt): How Secondary Micelles Are Formed. IJMS 2023, 24, 11853. <>
  • Xu Xu, Jiao Chaonan, Yang Hao, Chen Hao, Wang Jing: Oxidation of sodium cholate catalyzed by Au NPs and chiral selective binding of R- and S-binaphthyl derivatives. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2022, 648, 129209. <>
  • Poša Mihalj, Tepavčević Vesna, Grbović Ljubica, Mikulić Mira, Pavlović Ksenija: Hydrophobicity and self‐association (micellization) of bile salts with a lactone or lactam group in a steroid skeleton. J of Physical Organic Chem 2021, 34. <>
  • Vázquez-Tato M. Pilar, Seijas Julio A., Meijide Francisco, Fraga Francisco, de Frutos Santiago, Miragaya Javier, Trillo Juan Ventura, Jover Aida, Soto Victor H., Vázquez Tato José: Highly Hydrophilic and Lipophilic Derivatives of Bile Salts. IJMS 2021, 22, 6684. <>
  • Azum Naved, Rub Malik Abdul, Asiri Abdullah M.: Association behavior of bile salts binary mixtures in an aqueous system: A tensiometric and fluorometric study. J of Physical Organic Chem 2020, 33. <>
  • Macierzanka Adam, Torcello-Gómez Amelia, Jungnickel Christian, Maldonado-Valderrama Julia: Bile salts in digestion and transport of lipids. Advances in Colloid and Interface Science 2019, 274, 102045. <>
  • Poša Mihalj: Introduction of the novel coefficient of interaction in the micellar co-solubilisation of the binary mixture of structurally different solubilizates: Thermodynamic of the micellar co-solubilisation – A pseudophase approximation. Journal of Molecular Liquids 2018, 256, 320. <>
  • Malik Nisar Ahmad: Solubilization and Interaction Studies of Bile Salts with Surfactants and Drugs: a Review. Appl Biochem Biotechnol 2016, 179, 179. <>
  • Poša Mihalj, Popović Kosta, Ćirin Dejan, Agatić Zita Farkaš: Binary mixed micelles of triton X-100 and selected bile salts: Thermodynamic stabilization and pKa values of micellar bile acids. The Journal of Chemical Thermodynamics 2016, 103, 333. <>
  • Poša Mihalj, Bjedov Srđan, Škorić Dušan, Sakač Marija: Micellization parameters (number average, aggregation number and critical micellar concentration) of bile salt 3 and 7 ethylidene derivatives: Role of the steroidal skeleton II. Biochimica et Biophysica Acta (BBA) - General Subjects 2015, 1850, 1345. <>
  • Kabir-ud-Din, Al-dahbali Gamal A., Naqvi Andleeb Z., Akram Mohd.: Adsorption and Micellization Behavior of Mixtures of Amphiphilic Drugs with Small Amounts of Bile Salts. TSD 2015, 52, 271. <>
  • Farkaš Zita, Poša Mihalj, Tepavčević Vesna: Determination of pKa Values of Oxocholanoic Acids by Potentiometric Titration. J Surfact & Detergents 2014, 17, 609. <>
  • Poša Mihalj, Sebenji Ana: Determination of number-average aggregation numbers of bile salts micelles with a special emphasis on their oxo derivatives—The effect of the steroid skeleton. Biochimica et Biophysica Acta (BBA) - General Subjects 2014, 1840, 1072. <>
  • Poša Mihalj: Heuman indices of hydrophobicity of bile acids and their comparison with a newly developed and conventional molecular descriptors. Biochimie 2014, 97, 28. <>
  • Poša Mihalj, Bjedov Srđan, Sebenji Ana, Sakač Marija: Wittig reaction (with ethylidene triphenylphosphorane) of oxo-hydroxy derivatives of 5β-cholanic acid: Hydrophobicity, haemolytic potential and capacity of derived ethylidene derivatives for solubilisation of cholesterol. Steroids 2014, 86, 16. <>
  • Jójárt Balázs, Poša Mihalj, Fiser Béla, Szőri Milán, Farkaš Zita, Viskolcz Béla, Roccatano Danilo: Mixed Micelles of Sodium Cholate and Sodium Dodecylsulphate 1:1 Binary Mixture at Different Temperatures – Experimental and Theoretical Investigations. PLoS ONE 2014, 9, e102114. <>
  • Poša Mihalj, Csanádi János, Kövér Katalin E., Guzsvány Valéria, Batta Gyula: Molecular interactions between selected sodium salts of bile acids and morphine hydrochloride. Colloids and Surfaces B: Biointerfaces 2012, 94, 317. <>
  • Poša Mihalj, Ćirin Dejan: Mixed Micelles of Sodium Salts of Bile Acids and Tween 40: Effect of the Steroid Skeleton on the Coefficient of Interaction in Mixed Micelles. Ind. Eng. Chem. Res. 2012, 51, 14722. <>
  • Poša Mihalj, Pilipović Ana, Lalić Mladena, Popović Jovan: Determination and importance of temperature dependence of retention coefficient (RPHPLC) in QSAR model of nitrazepams’ partition coefficient in bile acid micelles. Talanta 2011, 83, 1634. <>
  • Posa Mihalj, Raseta Milena, Kuhajda Ksenija: A contribution to the study of hydrophobicity (lipophilicity) of bile acids with an emphasis on oxo derivatives of 5β-cholanoic acid. Chemical Industry 2011, 65, 115. <>