Collect. Czech. Chem. Commun. 2010, 75, 275-287
Published online 2010-03-08 11:33:58

Microwave synthesis of new biologically important 1,4-dihydropyridines containing benzothiazole moiety

Mithlesha, Pawan K. Pareeka, Hemraj Chippab, Ravikantc and Krishan G. Ojhaa,*

a Department of Pure and Applied Chemistry, Maharshi Dayanand Saraswati University, Ajmer, India
b Department of Microbiology, Maharshi Dayanand Saraswati University, Ajmer, India
c Hygia Institute of Pharmaceutical Education and Research, Lucknow, India


2,3,5,6-Tetrasubstituted-4-aryl-1-(6-ethoxybenzothiazol-2-yl)-1,4-dihydropyridines were synthesized by the reaction of 2-amino-6-ethoxybenzothiazole, an aromatic aldehyde and an active methylene compound in methanol by conventional or microwave irradiation method (solvent-free or with solid support). All compounds were tested for antibacterial and antifungal activities and the results were compared with standard drugs. Their acaricidal and antifeedant activities were also tested.

Keywords: Benzothiazole; 1,4-Dihydropyridine; Microwave synthesis; Antimicrobial activity; Acaricidal activity; Antifeedant activity.

References: 44 live references.