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Collect. Czech. Chem. Commun. 2006, 71, 1088-1098

Purine and Pyrimidine Nucleoside Analogs of 3'-C-Methyladenosine as Antitumor Agents

Loredana Cappellaccia, Palmarisa Franchettia, Riccardo Petrellia, Sara Riccionia, Patrizia Vitaa, Hiremagalur N. Jayaramb and Mario Grifantinia,*

a Dipartimento di Scienze Chimiche, Università di Camerino, 62032 Camerino, Italy
b Department of Biochemistry and Molecular Biology, Indiana University School of Medicine and Richard Roudebush VA Medical Center, Indianapolis, IN 46202, U.S.A.

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  • Yates Mary K., Seley-Radtke Katherine L.: The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold. Antiviral Research 2019, 162, 5. <>
  • Bege Miklós, Kiss Alexandra, Kicsák Máté, Bereczki Ilona, Baksa Viktória, Király Gábor, Szemán-Nagy Gábor, Szigeti M. Zsuzsa, Herczegh Pál, Borbás Anikó: Synthesis and Cytostatic Effect of 3’-deoxy-3’-C-Sulfanylmethyl Nucleoside Derivatives with d-xylo Configuration. Molecules 2019, 24, 2173. <>
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  • Petrelli Riccardo, Meli Maria, Vita Patrizia, Torquati Ilaria, Ferro Arianna, Vodnala Munender, D’Alessandro Natale, Tolomeo Manlio, Del Bello Fabio, Kusumanchi Praveen, Franchetti Palmarisa, Grifantini Mario, Jayaram Hiremagalur N., Hofer Anders, Cappellacci Loredana: From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3′-C-methyladenosine. Bioorganic & Medicinal Chemistry Letters 2014, 24, 5304. <>
  • Cappellacci Loredana, Petrelli Riccardo, Franchetti Palmarisa, Vita Patrizia, Kusumanchi Praveen, Kumar Mohineesh, Jayaram Hiremagalur N., Zhou Bingsen, Yen Yun, Grifantini Mario: Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3′-C-methyl-ribonucleosides as antitumor agents. European Journal of Medicinal Chemistry 2011, 46, 1499. <>
  • Cappellacci Loredana, Franchetti Palmarisa, Vita Patrizia, Petrelli Riccardo, Lavecchia Antonio, Jayaram Hiremagalur N., Saiko Philipp, Graser Geraldine, Szekeres Thomas, Grifantini Mario: Ribose-Modified Purine Nucleosides as Ribonucleotide Reductase Inhibitors. Synthesis, Antitumor Activity, and Molecular Modeling of N6-Substituted 3′-C-Methyladenosine Derivatives. J. Med. Chem. 2008, 51, 4260. <>
  • Couturier Sarah, Aljarah Mohamed, Gosselin Gilles, Mathé Christophe, Périgaud Christian: Synthesis of 3′-deoxy-3′-C-methyl-β-d-ribonucleoside analogs. Tetrahedron 2007, 63, 11260. <>