Collect. Czech. Chem. Commun. 2006, 71, 889-898

Studies on Improved Synthesis of 2'-Deoxyribonucleosides of Pyridazine Derivatives

Zygmunt Kazimierczuka,b,*, Jarosław Kamińskic and Flavio Meggiod

a Institute of Chemistry, Agricultural University, 159C Nowoursynowska St., 02-787 Warsaw, Poland
b Department of Experimental Pharmacology, Polish Academy of Science Medical Research Center, 5 Pawinskiego St., 02-106, Warsaw, Poland
c Institute of Industrial Chemistry, 8 Rydygiera St., 01-793 Warsaw, Poland
d Department of Biological Chemistry, University of Padua, viale G. Colombo 3, 35121 Padua, Italy


A number of 2'-deoxyribonucleosides of halogenated pyridazine derivatives were prepared by glycosylation of their respective potassium or DBU salts in acetone. The reaction yielded predominatly β-anomers that could be purified by simple crystallization or column chromatography. Of the studied pyridazines and deoxynucleosides, only 4-bromo-6-chloropyridazin-3-one and 6-chloro-2-(2'-deoxyribofuranosyl)pyridazin-3-one showed modest inhibition of CK2 kinase.

Keywords: Pyridazines; Nucleosides; Glycosidation; Glycosylation; CK2 inhibitors.

References: 14 live references.