Collect. Czech. Chem. Commun. 2006, 71, 179-189
https://doi.org/10.1135/cccc20060179

Physicochemical Properties of 9-(Alkylsulfanyl)- and 9-(Arylsulfanyl)acridine Derivatives and Their Interaction with (2-Hydroxypropyl)cyclodextrins

Irena Němcováa,*, Karel Nesměráka, Božena Kafkováa and Jan Sejbalb

a Department of Analytical Chemistry, Faculty of Science, Charles University, Albertov 6, CZ-128 43 Prague 2, Czech Republic
b Department of Organic and Nuclear Chemistry, Faculty of Science, Charles University, Albertov 6, CZ-128 43 Prague 2, Czech Republic

Abstract

Acid-base properties and aggregations of 9-(alkylsulfanyl)- and 9-(arylsulfanyl)acridine derivatives were studied as a part of systematic study of physicochemical properties of these compounds synthesized as potential drugs. The effect of the (2-hydroxypropyl)cyclodextrins on these properties and their association with the acridines was also followed.

Keywords: Cyclodextrins; Sulfanylacridines; Dissociation constants; Aggregation; Inclusion complexes; Association constants; Dissolution; NMR spectroscopy.

References: 29 live references.