Collect. Czech. Chem. Commun. 2005, 70, 269-291

Recent Advances in Chemistry and Applications of Substituted Poly(ethylene glycol)s

Miloš Sedlák

Department of Organic Chemistry, Faculty of Chemical Technology, University of Pardubice, nám.Čs. legií 565, 532 10 Pardubice, Czech Republic


Poly(ethylene glycol)s are well defined and easily accessible macromolecules with suitable properties for applications in chemistry, biotechnologies and medicine. The terminal hydroxy groups of poly(ethylene glycol)s can easily be converted into reactive functional groups by a number of routine reactions of organic chemistry. The chemical reagents or catalysts anchored to poly(ethylene glycol) chains were used in a number of syntheses including the enantioselective ones. Poly(ethylene glycol)s serve as carriers in combinatorial syntheses in the liquid phase. Coupling of poly(ethylene glycol)s with other polymers was used to prepare series of block copolymers having numerous applications. From the point of view of medical applications it is significant that substituted poly(ethylene glycol)s are non-toxic and resistant to recognition by the immunity system. That is why they are often used as carriers of many low-molecular-weight as well as high-molecular-weight medical drugs (drug delivery systems). In the conjugates with drugs their biological activity increases and their toxicity decreases. A review with 41 references.

Keywords: Poly(ethylene glycol); Poly(ethylene oxide); Poly(oxyethylene); PEG; PEGylation; Enantioselective synthesis; Combinatorial synthesis; Biomineralization; Carriers of medical drugs; Polymer supported reagents; Polymer supported ligands.

References: 116 live references.