Collect. Czech. Chem. Commun. 2005, 70, 188-197

Cathodic Stripping Voltammetry of 2-Thiouracils

Michał Kasprzak*, Witold Ciesielski and Sławomira Skrzypek

Zakład Analizy Instrumentalnej (Department of Instrumental Analysis), Uniwersytet Łódzki, Pomorska 163, 90-236 Łódź, Poland


Four 6-R-2-thiouracils (R = H, methyl, propyl, benzyl) were examined by differential pulse cathodic stripping voltammetry on mercury electrode. The research led to a very sensitive analytical method that allows their determination on nanomolar level. The detection limit of the 6-propyl derivative is as low as 1.0 × 10-9 mol dm-3. The procedure is very simple and utilizes only most common chemical reagents (such as acetate buffer). The buffer concentration plays an important role in the preconcentration stage, due to the adsorption processes accompanying electrode reactions. The new analytical method was tested with commercial samples of various antithyroid drugs.

Keywords: Differential pulse cathodic stripping voltammetry; Thiouracils; Antithyroid drugs; Pyrimidines; Nucleobases; Electrochemical determination; Electrochemistry.

References: 15 live references.