Collect. Czech. Chem. Commun. 2005, 70, 1615-1641

Synthesis of Peptidoglycan Units with UDP at the Anomeric Position

Thierry Liouxa, Roger Bussona, Jef Rozenskia, Martine Nguyen-Distècheb, Jean-Marie Frèreb and Piet Herdewijna,*

a Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium
b Centre d'Ingénierie des Protéines, Institut de Chimie B6a, Université de Liège, B-4000 Sart Tilman, Belgium


A series of UDP-disaccharide peptide compounds were synthesized as synthetic substrate analogues or potential inhibitors of glycosyl transferase. Fluorescent compounds have been prepared with the aim of developing a screening method for selecting transglycosylase inhibitors.

Keywords: Peptidoglycans; UDP-disaccharide; Dansyl; Dipeptides; Oligosaccharides; Glycopeptides; Amino sugars; Carbohydrates; Glycosidations; Glycosyl transferases.

References: 26 live references.