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Collect. Czech. Chem. Commun. 2004, 69, 689-702
https://doi.org/10.1135/cccc20040689

The Phase I Biotransformation of the Potential Antileukotrienic Drug Quinlukast in Rat Microsomes and Hepatocytes

Vladimír Wsóla,b,*, Barbora Szotákováa,b, Vendula Baliharováb, Luděk Šišperab, Michal Holčapekc, Lenka Kolářovác, Bohumila Suchanováb, Miroslav Kuchařd and Lenka Skálováa,b

a Department of Biochemical Sciences, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
b Research Centre LN00B125, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
c Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, nám. Čs. legií 565, 532 10 Pardubice, Czech Republic
d Research Institute for Pharmacy and Biochemistry, U Kabelovny 130, 102 37 Prague 10, Czech Republic

Crossref Cited-by Linking

  • Szotáková Barbora, Skálová Lenka, Baliharová Vendula, Dvorščaková Martina, Štorkánová Lenka, Šišpera Luděk, Wsól Vladimír: Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes. Journal of Pharmacy and Pharmacology 2010, 56, 205. <https://doi.org/10.1211/0022357023060>
  • Holčapek M., Kolářová L., Nobilis M.: High-performance liquid chromatography–tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites. Anal Bioanal Chem 2008, 391, 59. <https://doi.org/10.1007/s00216-008-1962-7>
  • Syrovatko Matej, Laznickova Alice, Laznicek Milan: Pharmacokinetics of radiolabelled quinlukast in rats. Journal of Pharmaceutical and Biomedical Analysis 2005, 38, 313. <https://doi.org/10.1016/j.jpba.2005.01.011>
  • Kuchař Miroslav, Brunová Bohumila, Junek Richard, Rodling Robert, Hájíček Josef, Panajotová Vladimíra, Jandera Antonín: The Antileukotrienic Derivatives and Homologues of [(Quinolin-2-ylmethoxy)sulfanyl]benzoic Acids with Reduced Lipophilicity. Collect. Czech. Chem. Commun. 2005, 70, 1357. <https://doi.org/10.1135/cccc20051357>