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Collect. Czech. Chem. Commun. 2004, 69, 589-602
https://doi.org/10.1135/cccc20040589

Metabolism of Carcinogenic 2-Nitroanisole in Rat, Rabbit, Porcine and Human Hepatic Cytosol

Markéta Mikšanováa, Petr Novákb, Eva Freic and Marie Stiborováa,*

a Department of Biochemistry, Charles University in Prague, Albertov 2030, 128 40 Prague 2, Czech Republic
b Institute of Microbiology, Academy of Sciences of the Czech Republic, 142 20 Prague 4, Czech Republic
c Department of Molecular Toxicology, German Cancer Research Center, 69120 Heidelberg, Germany

Crossref Cited-by Linking

  • Naiman Karel, Martínková Markéta, Schmeiser Heinz H., Frei Eva, Stiborová Marie: Human cytochrome-P450 enzymes metabolize N-(2-methoxyphenyl)hydroxylamine, a metabolite of the carcinogens o-anisidine and o-nitroanisole, thereby dictating its genotoxicity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2011, 726, 160. <https://doi.org/10.1016/j.mrgentox.2011.09.010>
  • Svobodová Martina, Martínková Markéta, Frei Eva, Stiborová Marie: Identification of human enzymes oxidizing a human metabolite of carcinogenic 2-nitroanisole, 2-nitrophenol. Evidence for its oxidative detoxification by human cytochromes P450. Collect. Czech. Chem. Commun. 2010, 75, 703. <https://doi.org/10.1135/cccc2010023>
  • Naiman Karel, Hodek Petr, Liberda Jiří, Schmeiser Heinz H., Frei Eva, Stiborová Marie: Rat liver microsomal metabolism of o-aminophenol and N-(2-methoxyphenyl)hydroxylamine, two metabolites of the environmental pollutant and carcinogen o-anisidine in humans. Collect. Czech. Chem. Commun. 2010, 75, 1229. <https://doi.org/10.1135/cccc2010077>
  • Stiborová Marie, Naiman Karel, Martínková Markéta, Martínek Václav, Svobodová Martina, Schmeiser Heinz, Frei Eva: Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)hydroxylamine with deoxyguanosine in DNA. Interdisciplinary Toxicology 2009, 2, 24. <https://doi.org/10.2478/v10102-009-0004-4>
  • Naiman Karel, Dračínská Helena, Martínková Markéta, Šulc Miroslav, Dračínský Martin, Kejíková Lucie, Hodek Petr, Hudeček Jirí, Liberda Jirí, Schmeiser Heinz H., Frei Eva, Stiborová Marie: Redox Cycling in the Metabolism of the Environmental Pollutant and Suspected Human Carcinogen o-Anisidine by Rat and Rabbit Hepatic Microsomes. Chem. Res. Toxicol. 2008, 21, 1610. <https://doi.org/10.1021/tx8001127>
  • Svobodová Martina, Dračínská Helena, Martínková Markéta, Hudeček Jiří, Hodek Petr, Frei Eva, Stiborová Marie: Oxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 - similarity between human and rat enzymes. Interdisciplinary Toxicology 2008, 1, 182. <https://doi.org/10.2478/v10102-010-0035-x>
  • Naiman Karel, Dračínská Helena, Dračínský Martin, Martínková Markéta, Martínek Václav, Hodek Petr, Štícha Martin, Frei Eva, Stiborová Marie: Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole. Interdisciplinary Toxicology 2008, 1, 218. <https://doi.org/10.2478/v10102-010-0045-8>
  • Bieler Christian A., Cornelius Michael G., Klein Reinhold, Arlt Volker M., Wiessler Manfred, Phillips David H., Schmeiser Heinz H.: DNA adduct formation by the environmental contaminant 3‐nitrobenzanthrone after intratracheal instillation in rats. Intl Journal of Cancer 2005, 116, 833. <https://doi.org/10.1002/ijc.21095>
  • Stiborová Marie, Mikšanová Markéta, Šulc Miroslav, Rýdlová Helena, Schmeiser Heinz H., Frei Eva: Identification of a genotoxic mechanism for the carcinogenicity of the environmental pollutant and suspected human carcinogeno-anisidine. Int. J. Cancer 2005, 116, 667. <https://doi.org/10.1002/ijc.21122>
  • Arlt Volker M., Stiborova Marie, Henderson Colin J., Osborne Martin R., Bieler Christian A., Frei Eva, Martinek Vaclav, Sopko Bruno, Wolf C. Roland, Schmeiser Heinz H., Phillips David H.: Environmental Pollutant and Potent Mutagen 3-Nitrobenzanthrone Forms DNA Adducts after Reduction by NAD(P)H:Quinone Oxidoreductase and Conjugation by Acetyltransferases and Sulfotransferases in Human Hepatic Cytosols. Cancer Research 2005, 65, 2644. <https://doi.org/10.1158/0008-5472.CAN-04-3544>
  • Rýdlová Helena, Mikšanová Markéta, Ryšlavá Helena, Stiborová Marie: CARCINOGENIC POLLUTANTS o-NITROANISOLE AND o-ANISIDINE ARE SUBSTRATES AND INDUCERS OF CYTOCHROMES P450. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2005, 149, 441. <https://doi.org/10.5507/bp.2005.077>