Collect. Czech. Chem. Commun. 2004, 69, 414-418

Preparation of Diethyl 1-(Alkyl/Aryl-2-amino-4-oxo-4,5-dihydropyrrol-3-yl)phosphonates

Anton V. Tverdokhlebov*, Andrey A. Tolmachev and Yulian M. Volovenko

Kiev National Taras Shevchenko University, Volodimirska str. 62, 01033 Kiev, Ukraine


The title compounds were prepared starting from diethyl (cyanomethyl)phosphonate by C-acylation with chloroacetyl chloride and subsequent amination with primary amines.

Keywords: Acylations; Alkylations; Phase-transfer catalysis; Phosphonates; Pyrrolones; Pyrroles; Nitriles.

References: 16 live references.