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Collect. Czech. Chem. Commun. 2004, 69, 1955-1970
https://doi.org/10.1135/cccc20041955

Covalent Analogues of DNA Base-Pairs and Triplets VII. Synthesis and Cytostatic Activity of Bis(purin-6-yl)acetylene and -diacetylene Nucleosides

Petr Nauš, Ivan Votruba and Michal Hocek*

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, CZ-166 10 Prague, Czech Republic

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  • Křováček M., Dvořák D.: Synthesis of Potentially Biologically Active 6-(1,3-Butadiynyl)purines. J. Heterocyclic Chem. 2015, 52, 40. <https://doi.org/10.1002/jhet.1938>
  • Standara Stanislav, Bouzková Kateřina, Straka Michal, Zacharová Zuzana, Hocek Michal, Marek Jaromír, Marek Radek: Interpretation of substituent effects on 13C and 15N NMR chemical shifts in 6-substituted purines. Phys Chem Chem Phys 2011, 13, 15854. <https://doi.org/10.1039/c1cp20680j>
  • Sedláček Ondřej, Břehová Petra, Pohl Radek, Holý Antonín, Janeba Zlatko: The synthesis of the 8-C-substituted 2,6-diamino-9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) derivatives by diverse cross-coupling reactions. Can. J. Chem. 2011, 89, 488. <https://doi.org/10.1139/V11-001>
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  • Bambuch Vítězslav, Otmar Miroslav, Pohl Radek, Masojídková Milena, Holý Antonín: C-Functionalization of 9-deazapurines by cross-coupling reactions. Tetrahedron 2007, 63, 1589. <https://doi.org/10.1016/j.tet.2006.12.008>
  • Naus Petr, Votruba Ivan, Hocek Michal: Covalent Analogues of DNA Base-Pairs and Triplets. Part 7. Synthesis and Cytostatic Activity of Bis(purin-6-yl)acetylene and -diacetylene Nucleosides. ChemInform 2005, 36. <https://doi.org/10.1002/chin.200514205>
  • Hocková Dana, Masojídková Milena, Holý Antonín: Sonogashira Cross-Coupling in the Synthesis of Acyclic Nucleoside Phosphonates: Preparation of 6-[(Phosphonomethoxy)alkynyl]- and 6-[(Phosphonomethoxy)alkyl]pyrimidines. Collect. Czech. Chem. Commun. 2005, 70, 247. <https://doi.org/10.1135/cccc20050247>
  • Turek Pavel, Kotora Martin, Hocek Michal, Votruba Ivan: Novel Method for Preparation of Highly Substituted 6-Arylpurines by Reactions of 6-Alkynylpurines with Zirconacyclopentadienes. Collect. Czech. Chem. Commun. 2005, 70, 339. <https://doi.org/10.1135/cccc20050339>