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Collect. Czech. Chem. Commun. 2003, 68, 792-800
https://doi.org/10.1135/cccc20030792

Cyclization of Semicarbazide Derivatives of 3-Methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-4-acetic Acid

Maria Dobosza,*, Monika Pituchaa, Izabela Dybalab and Anna E. Koziołb

a Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Staszica Str. 6, 20-081 Lublin, Poland
b Department of Crystallography, Faculty of Chemistry, Maria Curie-Sklodowska University, 20-031 Lublin, Poland

Crossref Cited-by Linking

  • Gultekin Ergün, Bekircan Olcay, Kolcuoğlu Yakup, Akdemir Atilla: Synthesis of new 1,2,4‐triazole–(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis. Archiv der Pharmazie 2021, 354. <https://doi.org/10.1002/ardp.202100058>
  • Pitucha Monika, Sobotka-Polska Karolina, Keller Radosław, Pachuta-Stec Anna, Mendyk Ewaryst, Kaczor Agnieszka A.: Synthesis and structure of new 1-cyanoacetyl-4-arylsemicarbazide derivatives with potential anticancer activity. Journal of Molecular Structure 2016, 1104, 24. <https://doi.org/10.1016/j.molstruc.2015.09.025>
  • Pitucha M.: A one-step synthesis of 4,4'-(methylenedi-4,1-phenylene)bis-[5-(2-thienylmethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one]. Chem Heterocycl Compd 2011, 47, 384. <https://doi.org/10.1007/s10593-011-0770-8>
  • Pitucha Monika, Karczmarzyk Zbigniew, Wysocki Waldemar, Kaczor Agnieszka A., Matosiuk Dariusz: Experimental and theoretical investigations on the keto–enol tautomerism of 4-substituted 3-[1-methylpyrrol-2-yl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives. J Molec Struct 2011, 994, 313. <https://doi.org/10.1016/j.molstruc.2011.03.041>
  • Zareef Muhammad, Arfan Muhammad, Iqbal Rashid, Parvez Masood: 4-Ethyl-3-(3-pyridyl)-1H-1,2,4-triazole-5(4H)-thione 0.095-hydrate. Acta Crystallogr E Struct Rep Online 2008, 64, o945. <https://doi.org/10.1107/S1600536808011744>
  • Siwek Agata, Paneth Piotr: Computational studies of the cyclization of thiosemicarbazides. J of Physical Organic Chem 2007, 20, 463. <https://doi.org/10.1002/poc.1179>
  • Braden Timothy M., Coffey D. Scott, Doecke Christopher W., LeTourneau Michael E., Martinelli Michael J., Meyer Christopher L., Miller Richard D., Pawlak Joseph M., Pedersen Steven W., Schmid Christopher R., Shaw Bruce W., Staszak Michael A., Vicenzi Jeffrey T.: A Convergent Kilogram-Scale Synthesis of the PPARα Agonist LY518674:  Discovery of a Novel Acid-Mediated Triazolone Synthesis. Org. Process Res. Dev. 2007, 11, 431. <https://doi.org/10.1021/op700040v>
  • Maliszewska-Guz Alicja, Wujec Monika, Pitucha Monika, Dobosz Maria, Chodkowska Anna, Jagiełło-Wójtowicz Ewa, Mazur Liliana, Kozioł Anna E.: Cyclization of 1-{[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}thiosemicarbazides to 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives and Their Pharmacological Properties. Collect. Czech. Chem. Commun. 2005, 70, 51. <https://doi.org/10.1135/cccc20050051>
  • Dobosz Maria, Pitucha Monika, Dybala Izabela, Koziol Anna E.: Cyclization of Semicarbazide Derivatives of 3‐Methyl‐5‐thioxo‐4,5‐dihydro‐1H‐1,2,4‐triazole‐4‐acetic Acid. ChemInform 2003, 34. <https://doi.org/10.1002/chin.200331141>