Collect. Czech. Chem. Commun. 2002, 67, 1335-1344

Preparation of (Fluoromethyl)- and (Difluoromethyl)imidazoles

Bohumil Dolensky and Kenneth L. Kirk*

Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, U.S.A


2-(Fluoromethyl)- and 2-(difluoromethyl)imidazoles, and 4-(fluoromethyl)- and 4-(difluoromethyl)imidazoles have been prepared by deoxyfluorination of (hydroxymethyl)imidazole or formylimidazole precursors.

Keywords: Fluorinated imidazoles; Deoxyfluorination; Fluorinated heterocycles; Deoxo-Fluor; Fluorinations; Aldehydes; Alcohols.

References: 32 live references.