Collect. Czech. Chem. Commun. 2002, 67, 1700-1708

Derivatives of (S)-{[2-(Methoxymethyl)pyrrolidin-1-yl]methyl}ferrocene - New Planar Chiral Ligands

Radovan Šebesta* and Marta Sališová

Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina, 842 15 Bratislava, Slovak Republic


New planar chiral amino-alcohol ferrocene ligands based on (S)-2-(methoxymethyl)pyrrolidine were synthesized and employed in the enantioselective addition of diethylzinc to benzaldehyde with enantioselectivity up to 82%. The effect of planar chirality was evaluated.

Keywords: Amino alcohols; Ferrocenes; Metallocenes; Ferrocenyl ligands; Planar chirality; Asymmetric catalysis; Diethylzinc addition.

References: 22 live references.