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Collect. Czech. Chem. Commun. 2001, 66, 959-972

Isolation of DT-Diaphorase [NAD(P)H Dehydrogenase (Quinone)] from Rat Liver Cytosol: Identification of New Enzyme Substrates, Carcinogenic Aristolochic Acids

Marie Stiborováa,*, Miroslav Hájeka, Hana Vošmikováa, Eva Freib and Heinz H. Schmeiserb

a Department of Biochemistry, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
b Department of Molecular Toxicology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

Crossref Cited-by Linking

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  • Bárta František, Levová Kateřina, Frei Eva, Schmeiser Heinz H., Arlt Volker M., Stiborová Marie: The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats—A comparative study. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2014, 768, 1. <>
  • Stiborová Marie, Frei Eva, Schmeiser Heinz, Arlt Volker, Martínek Václav: Mechanisms of Enzyme-Catalyzed Reduction of Two Carcinogenic Nitro-Aromatics, 3-Nitrobenzanthrone and Aristolochic Acid I: Experimental and Theoretical Approaches. IJMS 2014, 15, 10271. <>
  • Levova Katerina, Moserova Michaela, Nebert Daniel W., Phillips David H., Frei Eva, Schmeiser Heinz H., Arlt Volker M., Stiborova Marie: NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I. Toxicology and Applied Pharmacology 2012, 265, 360. <>
  • Stiborová Marie, Mareîs Jaroslav, Frei Eva, Arlt Volker M., Martínek Václav, Schmeiser Heinz H.: The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases. Environ and Mol Mutagen 2011, 52, 448. <>
  • Stiborová Marie, Frei Eva, Arlt Volker M., Schmeiser Heinz H.: Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy. Mutation Research/Reviews in Mutation Research 2008, 658, 55. <>
  • Vilímková Lenka, Páca Jan, Kremláčková Veronika, Páca Jan, Stiborová Marie: Isolation of cytoplasmic NADPH-dependent phenol hydroxylase and catechol-1,2-dioxygenase from Candida tropicalis yeast. Interdisciplinary Toxicology 2008, 1, 225. <>
  • Páca J., Kremláčková V., Turek M., Suchá V., Vilímková L., Páca J., Halecký M., Stiborová M.: Isolation and partial characterization of cytoplasmic NADPH-dependent phenol hydroxylase oxidizing phenol to catechol in Candida tropicalis yeast. Enzyme and Microbial Technology 2007, 40, 919. <>
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