Collect. Czech. Chem. Commun. 2001, 66, 1615-1622

DC Polarographic and UV Spectrometric Studies of Substituted Furo[3,2-b]- and Furo[2,3-b]pyrroles

Darina Romanováa,*, Anna Vachálkováb, Katarína Horváthováb and Alžbeta Krutošíkováa

a Department of Chemistry, Faculty of Natural Sciences, University of St. Cyril and Methodius, 917 01 Trnava, Slovak Republic
b Cancer Research Institute, Slovak Academy of Sciences, Vlarska 7, 833 91 Bratislava, Slovak Republic


The aim of the synthesis of substituted furo[3,2-b]- and furo[2,3-b]pyrroles was to discover biologically active compounds. On that account, their potential carcinogenicity was tested by DC polarographic assay in the presence of α-lipoic acid. Only one of the studied compounds showed a marginal carcinogenic activity, the other exhibited only a negligible carcinogenic potential under the conditions studied. Their apparent ionization constants, determined by spectrometric titration, were correlated with their structure. The results confirm that the presence of methyl, furyl and/or phenyl groups affects the ionization.

Keywords: Fused heterocycles; Furo[3,2-b]pyrroles; Furo[2,3-b]pyrroles; Furans; Pyrroles; DC polarography; Electroreductions; UV spectroscopy; Ionization constants; Carcinogens.

References: 22 live references.