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Collect. Czech. Chem. Commun. 2000, 65, 1374-1386
https://doi.org/10.1135/cccc20001374

Biotransformation of Benfluron by Rat Hepatic Cytochrome P450. Identification of Individual CYP-Enzymes Involved in Biotransformation of Benfluron, Prospective Antineoplastic Based on Benzo[c]fluorene

Kamil Hrubý, Eva Anzenbacherová, Pavel Anzenbacher* and Milan Nobilis

Institute of Experimental Biopharmaceutics, Joint Research Center of PRO.MED.CS Praha a.s. and Academy of Sciences of the Czech Republic, Heyrovského 1207, 500 02 Hradec Králové 2, Czech Republic

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  • Císař P., Nobilis M., Vybíralová Z., Holčapek M., Kolářová L., Pour M., Kuneš J., Klimeš J.: Disposition study of a new potential antineoplastic agent dimefluron in rats using high-performance liquid chromatography with ultraviolet and mass spectrometric detection. Journal of Pharmaceutical and Biomedical Analysis 2005, 37, 1059. <https://doi.org/10.1016/j.jpba.2004.09.031>
  • Kučera R., Nobilis M., Skálová L., Szotáková B., Císař P., Jira Th., Klimeš J., Wsól V.: Use of chiral liquid chromatography for the evaluation of stereospecificity in the carbonyl reduction of potential benzo[c]fluorene antineoplastics benfluron and dimefluron in various species. J  Pharm Biomed Anal 2005, 37, 1049. <https://doi.org/10.1016/j.jpba.2004.10.005>