Collect. Czech. Chem. Commun. 2000, 65, 1014-1028

Comparative Electrochemical Study of Some Phenothiazines with Carbon Paste, Solid Carbon Paste and Glass-Like Carbon Electrodes

Robert V. Sandulescu*, Simona M. Mirel, Radu N. Oprean and Simion Lotrean

Analytical Chemistry Department, University of Medicine and Pharmacy "Iuliu Haţieganu", 4 Pasteur St., RO-3400 Cluj-Napoca, Romania


In order to obtain modified electrodes with phenothiazines and to develop electrochemical methods for their determination in pharmaceutical formulations, promazine maleate, promethazine maleate and levomepromazine, were studied by linear sweep voltammetry using different types of working electrodes: carbon paste, solid carbon paste and glass-like carbon electrodes. A comparative electrochemical study of the above mentioned pheno- thiazines was performed in aqueous-alcoholic solutions, investigating the influence of pH, ionic strength and concentration on the current-potential curves. Linear sweep voltammetry in potential range from -0.1 to +1.3 V revealed that the oxidation potential and the current, strongly depend on the type of electrode and pH, the best results being obtained in acid buffer (pH 1.0). The current intensity depending linearly on the concentration in the range of 2.5·10-5-5·10-4 M promazine maleate, 2.5·10-5-2.5·10-4 M promethazine maleate and 6.2·10-5-1.2·10-3 M levomepromazine permits the development of electroanalytical methods to determine these phenothiazines in pharmaceuticals. The electrochemical determination yielded results comparable with spectrophotometric methods. Linear sweep voltammetry of carbon paste electrodes modified by incorporation of phenothiazines opens the possibility to use them as mediators in the design of some enzyme selective electrodes.

Keywords: Phenothiazines; Linear sweep voltammetry; Promazine maleate; Promethazine maleate; Levomepromazine; Electrochemical determination; Neuroleptics; Antihistaminics.

References: 23 live references.