Collect. Czech. Chem. Commun. 2000, 65, 549-554
https://doi.org/10.1135/cccc20000549

Synthesis and Resolution of a New C2-Symmetric Chiral Bis-Aniline, trans-1,2-Bis(2-aminophenyl)cyclopentane

Jin-Song Yang, Kazuhiro Kondo and Yasuoki Murakami*

School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan

References

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7. By shortening the time of palladium-catalyzed reaction from 20 to 9 h, the Buchwald amination of (1S,2S)-4 was carried out to afford (1S,2S)-2 in 4% yield with 95% ee, along with the mono-aniline 11 in 19% yield and the starting bis-triflate 4 in 45% yield (see below).