Collect. Czech. Chem. Commun. 2000, 65, 267-279

6-(Hydroxyphenyl)imidazo[2,1-b]thiazoles as Potential Antiinflammatory Agents: Effects on Human Neutrophil Functions

Aldo Andreania,*, Mirella Rambaldia, Alberto Leonia, Alessandra Locatellia, Rita Morigia, Serena Traniellob, Alessio Carianib, Olivia Rizzutib and Susanna Spisanib

a Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
b Department of Biochemistry and Molecular Biology, University of Ferrara, Via L. Borsari 46, 44100 Ferrara, Italy


Synthesis of 6-(hydroxyphenyl)imidazo[2,1-b]thiazoles related to levamisole from the corresponding methoxy derivatives is reported. These compounds were tested on in vitro neutrophil activation, namely locomotion induced by chemoattractants, superoxide generation and lysozyme degranulation triggered by agonists. These functions were evaluated after cell pulse with different concentrations of the drugs. Several derivatives showed significant inhibitory effects, in some cases more potent than the parent compound.

Keywords: Phenols; Antiinflammatory agents; Imidazo[2,1-b]thiazoles; Levamisole; NSAIDs; Neutrophil functions.

References: 41 live references.