Collect. Czech. Chem. Commun.
2000, 65, 1950-1958
https://doi.org/10.1135/cccc20001950
Crystal Structures of Two New Cyclosporin Clathrates
Michal Hušáka,b, Bohumil Kratochvílb, Ivana Císařovác and Alexandr Jegorovd,*
a Laboratory of Biomembranes, South Bohemian University, Branišovská 31, 370 05 České Budějovice, Czech Republic
b Department of Solid State Chemistry, Institute of Chemical Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
c Department of Inorganic Chemistry, Charles University, Hlavova 2030, 128 43 Prague 2, Czech Republic
d Galena a.s., Research Unit, Branišovská 31, 370 05 České Budějovice, Czech Republic
Abstract
Two isomorphous clathrates formed by dihydrocyclosporin A or cyclosporin V with tert-butyl methyl ether are reported and compared with the structures of related P21-symmetry cyclosporin clathrates. The cyclosporin molecules in both structures are associated via van der Waals interactions forming cavities occupied by solvent molecules (cyclosporin : tert-butyl methyl ether is 1 : 2).
Keywords: Cyclosporins; Cyclic peptides; Clathrates; X-Ray diffraction; Crystal structure; Immunosuppressants.
References: 10 live references.
