Collect. Czech. Chem. Commun. 2000, 65, 1805-1819

Hydrogenation of 3-(Dimethylamino)propionitrile Over Palladium Catalysts

Jiří Krupka*, Josef Pašek and Markéta Navrátilová

Department of Organic Technology, Institute of Chemical Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic


Hydrogenation of 3-(dimethylamino)propionitrile over palladium catalysts was studied. Besides the expected amines, N,N,N',N'-tetramethylpropane-1,3-diamine, N,N-dimethyl-N'-propylpropane-1,3-diamine, and N,N-bis[3-(dimethylamino)propyl]propylamine were found. Reaction pathways of their formation were discussed. Effects of reaction conditions, type of catalyst, and addition of ammonia or an amine into the charge on the hydrogenation selectivity were studied.

Keywords: Reductions; Hydrogenation; Nitriles; Amines; Heterogeneous catalysis; Palladium; 3-(Dimethylamino)propionitrile; Reaction mechanisms; Selectivity.

References: 21 live references.