Collect. Czech. Chem. Commun. 2000, 65, 99-105

A Covalently Bound Template in the Regioselective Synthesis of Bis(tetraazacrown)s

Martin Chadim, Miloš Buděšínský, Jana Hodačová and Jiří Závada*

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic


The two-carbon core in the tricyclic bis(aminal)s arising by condensation of linear tetramines with biacetyl serves as a template in the regioselective alkylation with 1,2,4,5-tetrakis(bromomethyl)benzene.

Keywords: Amines; Crown compounds; Cyclization; Macrocycles; Azacrown compounds; N-Ligands; Bis(aminals).

References: 15 live references.