Collect. Czech. Chem. Commun. 1999, 64, 1316-1324

7-(1-Cyanobut-3-en-1-yl)-N6-[(N,N-dimethylamino)methylene]adenine as a Starting Compound for the Synthesis of α-Branched Acyclic Analogues of N7-Isomer of Adenosine

Dana Hocková*, Milena Masojídková and Antonín Holý

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague 6, Czech Republic; 


7-(1-Cyanobut-3-en-1-yl)-N6-[(N,N-dimethylamino)methylene]adenine (2) was used as a multipurpose starting material for the synthesis of a series of α-branched acyclic analogues of N7-isomer of adenosine by further reactions on allyl (hydroxylation) and/or cyano group (hydrolysis, methanolysis or tetrazole formation).

Keywords: Nucleosides; Acyclic analogues; Purines; Nitriles; Antivirals.