Collect. Czech. Chem. Commun.
1999, 64, 1147-1153
https://doi.org/10.1135/cccc19991147
Three New Alkaloids, Convolutamines F and G, and Convolutamydine E, from the Floridian Marine Bryozoan Amathia convoluta
Yoshiaki Kamanoa,*, Ayano Kotakea, Hirofumi Hashimaa, Ichiro Hayakawaa, Hatsue Hiraidea, Hui-ping Zhanga, Haruhisa Kizub, Kanki Komiyamac, Masahiko Hayashic and George R. Pettitd
a Faculty of Science, Kanagawa University, Hiratsuka 259-1293, Japan
b Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa 920-11, Japan
c Kitasato Institute, Shirogane, Minato-ku, Tokyo 108-8642, Japan
d Cancer Research Institute and Department of Chemistry, Arizona State University, Tempe, AZ 85287-1604, U.S.A.
Abstract
Two new (2-phenylethyl)amine alkaloids, convolutamines F and G, and a dibromohydroxyoxindole alkaloid, convolutamydine E, have been isolated from the butan-1-ol soluble material of the Floridian marine bryozoan Amathia convoluta. Their structures were elucidated on the basis of spectroscopic data. Convolutamine F exhibited activity against KB, KB/VJ-300, and U937 cells. This compound also exhibited the inhibitory effects for cell division of fertilized sea urchin eggs.
Keywords: Marine natural products; Bryozoa; Amathia convoluta; (2-Phenylethyl)amine alkaloids; 3-Hydroxyindol-2(3H)-one; Convolutamine F; Convolutamine G; Convolutamydine E; Cytostatic activity; Isolation.
