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Collect. Czech. Chem. Commun. 1999, 64, 515-526
https://doi.org/10.1135/cccc19990515

Convenient Synthesis of More Complex 2-Substituted 4(3H)-Quinazolinones via Lithiation of 2-Alkyl-4(3H)-quinazolinones

Keith Smitha, Gamal A. El-Hitia,*, Mohamed F. Abdel-Megeedb and Mohamed A. Abdob

a Department of Chemistry, University of Wales Swansea, Swansea SA2 8PP, U.K.
b Department of Chemistry, Faculty of Science, Tanta University, Tanta, Egypt

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  • Xu Wei, Fu Hua: Amino Acids as the Nitrogen-Containing Motifs in Copper-Catalyzed Domino Synthesis of N-Heterocycles. J. Org. Chem. 2011, 76, 3846. <https://doi.org/10.1021/jo2002227>
  • Abdel-Megeed Mohamed F., Azaam Mohamed M., El-Hiti Gamal A.: 3-Arylazo-2-thioxo-2,3-dihydro-1H-quinazolin-4-ones as Azodisperse Dyes for Dyeing Polyester Fabrics. Monatsh. Chem. 2007, 138, 153. <https://doi.org/10.1007/s00706-006-0582-1>
  • Philipova I., Dobrikov G., Krumova K., Kaneti J.: Convenient synthesis of some 2‐substituted 4(3H)‐quinazolinone derivatives. Journal of Heterocyclic Chem 2006, 43, 1057. <https://doi.org/10.1002/jhet.5570430436>
  • Smith Keith, El-Hiti Gamal A., Hegazy Amany S.: Addition of alkyllithiums to 3H-quinazoline-4-thione and various substituted quinazoline derivatives; application in synthesis. Journal of Sulfur Chemistry 2005, 26, 121. <https://doi.org/10.1080/17415990500151472>
  • A. El-Hiti Gamal, F. Abdel-Megeed Mohamed: Synthesis of Glycosides Containing Quinazolin-4(3H)-one Ring System. HETEROCYCLES 2005, 65, 3007. <https://doi.org/10.3987/REV-05-602>
  • Mhaske Santosh B., Argade Narshinha P.: Regioselective Quinazolinone-Directed Ortho Lithiation of Quinazolinoylquinoline:  Practical Synthesis of Naturally Occurring Human DNA Topoisomerase I Poison Luotonin A and Luotonins B and E. J. Org. Chem. 2004, 69, 4563. <https://doi.org/10.1021/jo040153v>
  • A. El-Hiti Gamal: Synthesis of Substituted Quinazolin-4(3H)-ones and Quinazolines via Directed Lithiation. HETEROCYCLES 2000, 53, 1839. <https://doi.org/10.3987/REV-00-535>
  • Smith Keith, El‐Hiti Gamal A., Abdel‐Megeed Mohamed F., Abdo Mohamed A.: ChemInform Abstract: Convenient Synthesis of More Complex 2‐Substituted 4(3H)‐Quinazolinones via Lithiation of 2‐Alkyl‐4(3H)quinazolinones. ChemInform 1999, 30. <https://doi.org/10.1002/chin.199938153>