Collect. Czech. Chem. Commun. 1999, 64, 288-298

Synthesis of New Potential Bis-Intercalators Based on Chiral Pyridine-2,6-dicarboxamides

Abd El-Galil Amra, Osama I. Abd El-Salama, Abd El-Hamid Attiaa and Ivan Stiborb,*

a Department of Organic Chemistry, National Research Centre, Dokki, Cairo-12622, Egypt
b Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic


Potential bis-intercalating compounds N,N-dibenzylidene-N2,N2'-(pyridine-2,6-dicarbonyl)- di(aminoacidhydrazides) 4a-4j, N,N'-substituted pyridine-2,6-bis(carbohydrazides) 5a-5d and N,N'-substituted N2N2'-bis(pyridine-2,6-dicarbonyl)di(aminoacidhydrazides) 6a-6g, both racemic and optically active, can be easily synthesized from pyridine-2,6-bis(carbohydrazide), natural amino acids and aromatic aldehydes or anhydrides of aromatic ortho-dicarboxylic acids.

Keywords: DNA intercalation; Chiral intercalators; Pyridine-2,6-dicarboxamides; Amino acids; Naphthalimides; Antimicrobial activity.