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Collect. Czech. Chem. Commun. 1999, 64, 242-256
https://doi.org/10.1135/cccc19990242

Synthesis of Quaternary 1-[2-(Phosphonomethoxy)ethyl] Derivatives of 2,4-Diaminopyrimidine and Related Acyclic Nucleotide Analogs

Antonín Holýa,*, Miloš Buděšínskýa, Jaroslav Podlahab and Ivana Císařováb

a Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
b Department of Inorganic Chemistry, Charles University, 128 40 Prague 2, Czech Republic

Crossref Cited-by Linking

  • Hützler Wilhelm Maximilian, Egert Ernst, Bolte Michael: 6-Propyl-2-thiouracilversus6-methoxymethyl-2-thiouracil: enhancing the hydrogen-bonded synthon motif by replacement of a methylene group with an O atom. Acta Crystallogr C Struct Chem 2016, 72, 634. <https://doi.org/10.1107/S2053229616011281>
  • Hützler Wilhelm Maximilian, Egert Ernst, Bolte Michael: One barbiturate and two solvated thiobarbiturates containing the triply hydrogen-bondedADA/DADsynthon, plus one ansolvate and three solvates of their coformer 2,4-diaminopyrimidine. Acta Crystallogr C Struct Chem 2016, 72, 705. <https://doi.org/10.1107/S205322961601336X>
  • Blindauer Claudia A., Sigel Astrid, Operschall Bert P., Holý Antonin, Sigel Helmut: Extent of Intramolecular π Stacks in Aqueous Solution in Mixed-Ligand Copper(II) Complexes Formed by Heteroaromatic Amines and 1-[2-(Phosphonomethoxy)ethyl]cytosine (PMEC), a Relative of Antivirally Active Acyclic Nucleotide Analogues (Part 72)[1, 2]. Z. anorg. allg. Chem. 2013, 639, 1661. <https://doi.org/10.1002/zaac.201300095>
  • Holy Antonin, Budesinsky Milos, Podlaha Jaroslav, Cisarova Ivana: ChemInform Abstract: Synthesis of Quaternary 1-[2-(Phosphonomethoxy)ethyl] Derivatives of 2,4-Diaminopyrimidine and Related Acyclic Nucleotide Analogues. ChemInform 2010, 30, no. <https://doi.org/10.1002/chin.199931264>
  • Sparrow Christopher R., Walker Edwin H., Fronczek Frank R.: 2-Amino-1-(2-carboxylatoethyl)pyrimidin-1-ium monohydrate. Acta Crystallogr E Struct Rep Online 2010, 66, o3156. <https://doi.org/10.1107/S1600536810045332>
  • Fernández‐Botello Alfonso, Escuer Albert, Solans Xavier, Font‐Bardía Mercè, Holý Antonin, Sigel Helmut, Moreno Virtudes: New Ternary Complexes of Copper(II) with 2,2′‐Bipyridine (Bpy) and Phosphocholine (PCh – ) or the Quaternary 1‐(2‐Phosphonomethoxy)ethyl Derivative of 2,4‐Diaminopyrimidine (PMEDAPy – ). Eur. J. Inorg. Chem. 2007, 2007, 1867. <https://doi.org/10.1002/ejic.200601002>
  • Fernández-Botello Alfonso, Holý Antonı́n, Moreno Virtudes, Sigel Helmut: Stability and structure of binary and ternary metal ion complexes in aqueous solution of the quaternary 1-[2-(phosphonomethoxy)ethyl] derivative of 2,4-diaminopyrimidine (PMEDAPy−). Properties of an acyclic nucleotide analogue. Polyhedron 2003, 22, 1067. <https://doi.org/10.1016/S0277-5387(03)00093-7>
  • Holý Antonín, Votruba Ivan, Masojídková Milena, Andrei Graciela, Snoeck Robert, Naesens Lieve, De Clercq Erik, Balzarini Jan: 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with Antiviral Activity. J. Med. Chem. 2002, 45, 1918. <https://doi.org/10.1021/jm011095y>
  • Holý Antonín, Votruba Ivan, Tloušťová Eva, Masojídková Milena: Synthesis and Cytostatic Activity of N-[2-(Phosphonomethoxy)alkyl] Derivatives of N6-Substituted Adenines, 2,6-Diaminopurines and Related Compounds. Collect. Czech. Chem. Commun. 2001, 66, 1545. <https://doi.org/10.1135/cccc20011545>