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Collect. Czech. Chem. Commun. 1999, 64, 217-228

Antitumor Agents. 192. Antitubulin Effect and Cytotoxicity of C(7)-Oxygenated Allocolchicinoids

Jian Guana, Xiao-Kang Zhua, Arnold Brossia, Yoko Tachibanaa, Kenneth F. Bastowa, Pascal Verdier-Pinardb, Ernest Hamelb, Andrew T. McPhailc and Kuo-Hsiung Leea,*

a Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, U.S.A.
b Laboratory of Drug Discovery Research and Development, Development Therapeutics Program, Division of Cancer Treatment, Diagnosis and Centers, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, MD 21702, U.S.A.
c Paul M. Gross Chemical Laboratory, Duke University, Durham, NC 27708; U.S.A.

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  • Liu Xin, Hu Ya-Jian, Chen Bo, Min Long, Peng Xiao-Shui, Zhao Jing, Li Shaoping, Wong Henry N. C., Li Chuang-Chuang: Asymmetric Total Syntheses of Colchicine, β-Lumicolchicine, and Allocolchicinoid N-Acetylcolchinol-O-methyl Ether (NCME). Org. Lett. 2017, 19, 4612. <>
  • Yadav Dharmendra B., Taleli Lebusetsa, van der Westhuyzen Alet E., Fernandes Manuel A., Dragoun Maxim, Prokop Aram, Schmalz Hans‐Günther, de Koning Charles B., van Otterlo Willem A. L.: Synthesis of Diverse 6‐Oxa‐allocolchicinoids by a Suzuki–Miyaura Coupling, Acid‐Catalyzed Intramolecular Transacetali­zation Strategy. Eur J Org Chem 2015, 2015, 5167. <>
  • Alcaide Benito, Almendros Pedro, Quirós M. Teresa, López Ramón, Menéndez María I., Sochacka-Ćwikła Aleksandra: Unveiling the Reactivity of Propargylic Hydroperoxides under Gold Catalysis. J. Am. Chem. Soc. 2013, 135, 898. <>
  • Tang Changhua, Li Ziyuan, Wang Yiyun, Xu Jinyi, Kong Lingyi, Yao Hequan, Wu Xiaoming: First total synthesis of tenuifolin via PIFA mediated oxidative biaryl coupling. Tetrahedron Letters 2011, 52, 3275. <>
  • Djurdjevic Sinisa, Yang Fei, Green James R.: Intramolecular Nicholas Reactions in the Synthesis of Dibenzocycloheptanes. Synthesis of Allocolchicine NSC 51046 and Analogues and the Formal Synthesis of (−)-Allocolchicine. J. Org. Chem. 2010, 75, 8241. <>
  • Lee Kuo-Hsiung: Discovery and Development of Natural Product-Derived Chemotherapeutic Agents Based on a Medicinal Chemistry Approach. J. Nat. Prod. 2010, 73, 500. <>
  • Singh B.P., Behera B.K.: Regulation of tacrolimus production by altering primary source of carbons and amino acids. Letters in Applied Microbiology 2009, 49, 254. <>
  • Djurdjevic Sinisa, Green James R.: Allocolchicines via Intramolecular Nicholas Reactions:  The Synthesis of NSC 51046. Org. Lett. 2007, 9, 5505. <>
  • Besong Gilbert, Jarowicki Krzysztof, Kocienski Philip J., Sliwinski Eric, Boyle F. Thomas: Synthesis of (S)-(−)-N-acetylcolchinol using intramolecular biaryl oxidative coupling. Org. Biomol. Chem. 2006, 4, 2193. <>
  • Lee Kuo-Hsiung, Nakagawa-Goto Kyoko, Katherine Jung M., Hamel Ernest, Wu Chin-Chung, F. Bastow Kenneth, Brossi Arnold, Ohta Shunsaku: Antitumor Agents 238. Anti-tubulin and in vitro Cytotoxic Effects of N-Substituted Allocolchicinoids. HETEROCYCLES 2005, 65, 541. <>
  • Bergemann Silke, Brecht René, Büttner Frank, Guénard Daniel, Gust Ronald, Seitz Gunther, Stubbs Milton T., Thoret Sylviane: Novel B-ring modified allocolchicinoids of the NCME series: design, synthesis, antimicrotubule activity and cytotoxicity. Bioorganic & Medicinal Chemistry 2003, 11, 1269. <>
  • Han Shiqing, Hamel Ernest, Bastow Kenneth F, McPhail Andrew T, Brossi Arnold, Lee Kuo-Hsiung: Antitumor agents. Part 215:. Bioorganic & Medicinal Chemistry Letters 2002, 12, 2851. <>
  • Li Qun, Sham Hing L: Discovery and development of antimitotic agents that inhibit tubulin polymerisation for the treatment of cancer. eotp 2002, 12, 1663. <>
  • Zhang Shun-Xiang, Feng Jun, Kuo Sheng-Chu, Brossi Arnold, Hamel Ernest, Tropsha Alexander, Lee Kuo-Hsiung: Antitumor Agents. 199. Three-Dimensional Quantitative Structure−Activity Relationship Study of the Colchicine Binding Site Ligands Using Comparative Molecular Field Analysis. J. Med. Chem. 2000, 43, 167. <>
  • Guan Jian, Zhu Xiao‐Kang, Brossi Arnold, Tachibana Yoko, Bastow Kenneth F., Verdier‐Pinard Pascal, Hamel Ernest, McPhail Andrew T., Lee Kuo‐Hsiung: ChemInform Abstract: Antitumor Agents. Part 192. Antitubulin Effect and Cytotoxicity of C(7)‐Oxygenated Allocolchicinoids. ChemInform 1999, 30. <>