Collection of Czechoslovak Chemical Communications - digital archive 

Abstract

The cross-interaction constant, ρ_ij, is a second derivative parameter representing a change in the intensity of interaction between the two reacting partners (or fragments) i and j in a reaction. It can be either an activation or a reaction parameter. The sign and magnitude of ρ_ij have important mechanistic significances and are useful as a tool for the studies of organic reaction mechanism. We have presented several more important applications of the cross-interaction constants. A review with 42 references.

Keywords: Cross-interaction constants; Transition-state structures; Mechanistic criteria; Reactivity-selectivity principle; Reaction kinetics; Nucleophilic substitutions; Review.