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Collect. Czech. Chem. Commun. 1998, 63, 857-869
https://doi.org/10.1135/cccc19980857

To the Mechanism of 2-Nitroanisole Carcinogenicity: in vitro Metabolism of 2-Nitroanisole Mediated by Peroxidasesand Xanthine Oxidase

Marie Stiborováa, Heinz H. Schmeiserb and Eva Freib

a Department of Biochemistry, Charles University, 128 40 Prague 2, Czech Republic
b Department of Molecular Toxicology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

Crossref Cited-by Linking

  • Naiman Karel, Martínková Markéta, Schmeiser Heinz H., Frei Eva, Stiborová Marie: Human cytochrome-P450 enzymes metabolize N-(2-methoxyphenyl)hydroxylamine, a metabolite of the carcinogens o-anisidine and o-nitroanisole, thereby dictating its genotoxicity. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2011, 726, 160. <https://doi.org/10.1016/j.mrgentox.2011.09.010>
  • Svobodová Martina, Martínková Markéta, Frei Eva, Stiborová Marie: Identification of human enzymes oxidizing a human metabolite of carcinogenic 2-nitroanisole, 2-nitrophenol. Evidence for its oxidative detoxification by human cytochromes P450. Collect. Czech. Chem. Commun. 2010, 75, 703. <https://doi.org/10.1135/cccc2010023>
  • Stiborová Marie, Naiman Karel, Martínková Markéta, Martínek Václav, Svobodová Martina, Schmeiser Heinz, Frei Eva: Genotoxic mechanisms for the carcinogenicity of the environmental pollutants and carcinogens o-anisidine and 2-nitroanisole follow from adducts generated by their metabolite N-(2-methoxyphenyl)hydroxylamine with deoxyguanosine in DNA. Interdisciplinary Toxicology 2009, 2, 24. <https://doi.org/10.2478/v10102-009-0004-4>
  • Svobodová Martina, Dračínská Helena, Martínková Markéta, Hudeček Jiří, Hodek Petr, Frei Eva, Stiborová Marie: Oxidation of carcinogenic 2-nitroanisole by rat cytochromes P450 - similarity between human and rat enzymes. Interdisciplinary Toxicology 2008, 1, 182. <https://doi.org/10.2478/v10102-010-0035-x>
  • Naiman Karel, Dračínská Helena, Dračínský Martin, Martínková Markéta, Martínek Václav, Hodek Petr, Štícha Martin, Frei Eva, Stiborová Marie: Cytochrome P450-mediated metabolism of N-(2-methoxyphenyl)-hydroxylamine, a human metabolite of the environmental pollutants and carcinogens o-anisidine and o-nitroanisole. Interdisciplinary Toxicology 2008, 1, 218. <https://doi.org/10.2478/v10102-010-0045-8>
  • Mikšanová Markéta, Novák Petr, Frei Eva, Stiborová Marie: Metabolism of Carcinogenic 2-Nitroanisole in Rat, Rabbit, Porcine and Human Hepatic Cytosol. Collect. Czech. Chem. Commun. 2004, 69, 589. <https://doi.org/10.1135/cccc20040589>
  • Núñez-Vergara Luis J., Bollo S., Atria A. M., Carbajo J., Gunckel S., Squella J. A.: Free Radical Formation and Characterization of Nitroanisole Isomer Reduction in Different Media. J. Electrochem. Soc. 2002, 149, E374. <https://doi.org/10.1149/1.1503078>
  • Mikšanová Markéta, Hudeček Jiří, Páca Jan, Stiborová Marie: To the Mechanism of Horseradish Peroxidase-Mediated Degradation of a Recalcitrant Dye Remazol Brilliant Blue R. Collect. Czech. Chem. Commun. 2001, 66, 663. <https://doi.org/10.1135/cccc20010663>