Collect. Czech. Chem. Commun. 1998, 63, 698-712

Azachalcone Derivatives and Their Bis Substituted Analogs as Novel Antimycobacterial Agents

Václav Kozmíka, Pavel Lhotáka, Želmíra Odlerováb and Jaroslav Palečeka

a Department of Organic Chemistry, Prague Institute of Chemical Technology, 166 28 Prague 6, Czech Republic
b Institute of Preventive and Clinical Medicine, 833 01 Bratislava, Slovak Republic


Fifteen novel substituted azachalcone derivatives and their bis substituted analogs were prepared from 3,5-diacetyl-2,6-dimethylpyridine by the Claisen-Schmidt condensation. The influence of the reaction conditions on the yield of mono- and bischalcones was studied to optimize the reaction. Spectral characteristics along with preliminary results of antimycobacterial activity of selected compounds are given.

Keywords: Azachalcones; Pyridines; 1,1'-(Pyridine-3,5-diyl)bis(3-arylprop-2-en-1-ones); Antimycobacterial activity; Antituberculotics.