Collect. Czech. Chem. Commun. 1998, 63, 646-654

17a-Oxa-17a-homobrassinosteroid Analogues

Ladislav Kohouta, Barbora Slavíkováa and Miroslav Strnadb

a Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
b Institute of Experimental Botany, Academy of Sciences of the Czech Republic, 78 371 Olomouc, Czech Republic


Synthesis of a 17a-oxa-17a-homobrassinosteroids, i.e. brassinosteroids having two lactone rings, is described. In the bean second internode bioassay, dilactone 16 was the most effective of the compounds synthesized. In the same test, the castasterone analogue 12 exhibited a growth-retarding effect.

Keywords: Steroids; Brassinolide analogues; Brassinosteroid dilactones; Second bean internode bioassay; Brassinolide activity.