Collect. Czech. Chem. Commun. 1998, 63, 1671-1677

Antineoplastic Agents 385. The Isolation and Structure of a Scalarane-Type Sesterterpene from the Indian Ocean Porifera Hyrtios erecta

George R. Pettita, Zbigniew A. Cichacza, Rui Tana, Delbert L. Heralda, Noeleen Melodya, Michael S. Hoarda, Dennis L. Doubeka and John N. A. Hooperb

a Cancer Research Institute and Department of Chemistry, Arizona State University, Tempe, Arizona 85287-2404, U.S.A.
b Queensland Museum, P.O. Box 3300 S. Brisbane, Queensland 4101, Australia


Bioassay-guided separation techniques were employed to isolate (3.3·10-7% yield) a new murine P388 lymphocytic leukemia cell line inhibitor (ED50 2.9 μg/ml) 12-O-deacetyl-19-deoxyscalarin from extracts of the Republic of Maldives marine sponge Hyrtios erecta. The structure was deduced using high field 2D NMR and high resolution mass spectral methods and confirmed by X-ray crystal structure determination.

Keywords: Natural products; Terpenes; Sesterterpenes; Scalorolides; Marine sponge; NMR spectroscopy; X-Ray diffraction; Crystal structure.