Collect. Czech. Chem. Commun.
1998, 63, 94-102
https://doi.org/10.1135/cccc19980094
Synthesis and Antifungal Activity of New Indolylthiazinone Derivatives
Milan Dzurillaa, Peter Kutschya, Jalpa P. Tewarib, Martin Ružinskýa, Stanislav Šenvickýa and Vladimír Kováčikc
a Department of Organic Chemistry, Faculty of Natural Sciences, P. J. Šafárik University, Moyzesova 11, 041 67 Košice, Slovak Republic
b Department of Agricultural, Food and Nutrition Science, Faculty of Agriculture, Forestry and Home Economics, University of Alberta, Canada T6G2P5
c Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, 842 38 Bratislava, Slovak Republic
Abstract
New 6-(indol-3-yl)-5,6-dihydro-4H-1,3-thiazin-4-one derivatives were prepared by boron trifluoride catalyzed intramolecular cyclization of N'-substituted N-[3-(indol-3-yl)propenoyl]thioureas and by the reaction of 3-(indol-3-yl)propenoyl isothiocyanate with sodium hydrogensulfide. Antifungal activity of the prepared compounds was studied using the fungi Alternaria brassicae and Alternaria brassicicola.
Keywords: Indoles; Thiazines; Thioureas; Isothiocyanates; Indolylthiazinones; Antifungal activity.
