Collect. Czech. Chem. Commun. 1996, 61, 1093-1101
https://doi.org/10.1135/cccc19961093

5-Alkyl-2-pyrazinecarboxamides, 5-Alkyl-2-pyrazinecarbonitriles and 5-Alkyl-2-acetylpyrazines as Synthetic Intermediates for Antiinflammatory Agents

Veronika Opletalováa, Asmita Patelb, Michael Boultonc, Alice Dundrováa, Eva Lacinováa, Marta Převorováa, Martina Appeltauerováa and Milada Coufalováa

a Department of Pharmaceutical Chemistry and Drug Control, Charles University, 500 05 Hradec Králové, Czech Republic
b School of Pharmacy and Biomedical Science, University of Portsmouth, King Henry I Street, Portsmouth PO1 2DZ, United Kingdom
c Department of Biomolecular Screening, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire SG1 2NY, United Kingdom

Abstract

2-Pyrazinecarbonitrile, 2-acetylpyrazine, 5-alkyl-2-pyrazinecarboxamides, 5-alkyl-2-pyrazinecarbonitriles and 5-alkyl-2-acetylpyrazines were prepared as intermediates for use in synthesis of potential antiinflammatory agents. The results of the homolytic alkylation of pyrazinecarboxamide were compared with published data. 2-Acetylpyrazine and its 5-(1,1-dimethylethyl) derivative were screened for biological activity, but no interesting effect was found.

Keywords: Pyrazinecarboxamide; Pyrazinecarbonitrile; Homolytic alkylation; 5-Alkyl-2-acetylpyrazines; Antiinflammatory agents intermediates.