Collect. Czech. Chem. Commun. 1996, 61, 1073-1076
https://doi.org/10.1135/cccc19961073

One-Pot Esterification and Selective 3α-Acetylation of Cholic and Deoxycholic Acid

Ksenija Kuhajda, Julijan Kandrač, Vera Cirin-Novta and Dušan Miljković

Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, Yugoslavia

Abstract

A simple one-pot esterification and selective 3α-acetylation of cholic and deoxycholic acid with selected esters of acetic acid (ethyl, propyl and butyl) in the presence of catalytic amount of 4-toluenesulfonic acid and water has been described. The yields of the obtained esters varied in range of 74-95%.

Keywords: Bile acids; Selective 3alpha-acetylation; Esterification.