Collect. Czech. Chem. Commun. 1996, 61, 432-436
https://doi.org/10.1135/cccc19960432

Reaction of O-Alkyl-N-substituted Iminothiocarbonates with Bromoacetyl Bromide. A General Method for the Synthesis of 3-Substituted 1,3-Thiazolidine-2,4-diones

Ján Imrich, Juraj Bernát, Pavol Kristian, Tatiana Bušová and Slávka Hočová

Department of Organic Chemistry, P. J. Šafárik University, 041 67 Košice, Slovak Republic

Abstract

Reaction of sodium salts of O-methyl-N-substituted iminothiocarbonates with bromoacetyl bromide represents a new general method for preparation of 3-substituted 1,3-thiazolidine-2,4-diones in good yields and high purity. The structure of the synthesized products has been confirmed by 1H NMR, 13C NMR, IR and mass spectroscopy as well as by independent synthesis.

Keywords: Isothiocyanates; Iminothiocarbonates; 1,3-Thiazolidine-2,4-diones.