Collect. Czech. Chem. Commun. 1995, 60, 1551-1554

Homolytic Acetylation of 2,5-Dimethylpyrazine

Veronika Opletalováa, Jiří Hartla, Asmita Patelb and Michael Boultonc

a Department of Pharmaceutical Chemistry and Drug Control,Faculty of Pharmacy, Charles University, 500 05 Hradec Králové, Czech Republic
b School of Pharmacy and Biomedical Science, University of Portsmouth, King Henry I Street, Portsmouth PO1 2DZ, United Kingdom
c Department of Biomolecular Screening, Glaxo Wellcome Medicines Research Centre, Stevenage, Hertfordshire, SG1 2NY, United Kingdom


2,5-Dimethylpyrazine prepared by the method described in the literature was acetylated by means of acetaldehyde, tert-butylhydroperoxide and ferrous sulfate. 2,5-Diacetyl-3,6-dimethylpyrazine and 2-acetyl-3,5,6-trimethylpyrazine were obtained. The structure of the products was confirmed by NMR and mass spectral data, and the compounds were screened for biological activity using 20 different screens. No interesting biological activity was found.