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Abstract

This paper describes a new synthesis of monomeric 2-/(2-methyl-2-propenoyl)oxy/ethyl esters of prostaglandins (IIa-IId). The monomeric esters were prepared by reaction of an alkali metal or triethylammonium salt of a prostaglandin of the F_2a or A₂ series (Ia-Id) with 2-iodoethyl (IIIa) or 2-bromoethyl-2-methyl-2-propenoate (IIIb) in good to high yields. These monomers have been used for preparing reversible anchoring of prostaglandins on a modified three-dimensional biocompatible hydrogels prepared by copolymerization with 2-hydroxyethyl 2-methyl-2-propenoate. The application of functionalized polymers could be used in drug forms with controlled liberation of biologically active PG derivatives.