Collect. Czech. Chem. Commun. 1995, 60, 697-704

The Amino and Deamino Analogues of 8-D-Homoarginine-Vasopressin with p-Substituted Phenylalanine in Position 2 in Activation of Factor VIII and Tissue Plasminogen Activator in Primates

Hans Vilhardta, Tomislav Barthb, Miroslava Žertováb, Zdenko Procházkab and Jiří Velekb

a Department of Medical Physiology C, University of Copenhagen, DK-2100 Copenhagen, Denmark
b Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic


The replacement of L-Tyr in dDAVP by L-Tyr(Me), L- or D-Phe(pMe), L- or D-Phe(pEt) in combination with substitution of D-arginine by D-homoarginine resulted in dissociation of Factor VIII and tPA activating properties or in abilities to decrease the levels of circulating Factor VIII and tPA levels in blood of squirrel monkeys.