The Amino and Deamino Analogues of 8-D-Homoarginine-Vasopressin with <i>p</i>-Substituted Phenylalanine in Position 2 in Activation of Factor VIII and Tissue Plasminogen Activator in Primates

Vilhardt, Hans; Barth, Tomislav; Žertová, Miroslava; Procházka, Zdenko; Velek, Jiří

doi:10.1135/cccc19950697

CCCC > Archive > 1995, Volume 60 > Issue 4 > p. 697

The Amino and Deamino Analogues of 8-D-Homoarginine-Vasopressin with p-Substituted Phenylalanine in Position 2 in Activation of Factor VIII and Tissue Plasminogen Activator in Primates

Hans Vilhardt^a, Tomislav Barth^b, Miroslava Žertová^b, Zdenko Procházka^b and Jiří Velek^b

^a Department of Medical Physiology C, University of Copenhagen, DK-2100 Copenhagen, Denmark
^b Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic

Abstract

The replacement of L-Tyr in dDAVP by L-Tyr(Me), L- or D-Phe(pMe), L- or D-Phe(pEt) in combination with substitution of D-arginine by D-homoarginine resulted in dissociation of Factor VIII and tPA activating properties or in abilities to decrease the levels of circulating Factor VIII and tPA levels in blood of squirrel monkeys.

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The Amino and Deamino Analogues of 8-D-Homoarginine-Vasopressin with p-Substituted Phenylalanine in Position 2 in Activation of Factor VIII and Tissue Plasminogen Activator in Primates

Abstract