Collect. Czech. Chem. Commun. 1994, 59, 1175-1202

Structure of Sesquiterpenic Lactones of Some Species of Subtribe Centaureinae DUMORT.

Miloš Buděšínskýa, Gerard Nowakb, Urszula Rychłewskac, Derek J. Hodgsond, David Šamana, Włodzimierz M. Daniewskie, Bohdan Drożdżb and Miroslav Holuba

a Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 166 10 Prague 6, Czech Republic
b Department of Medical Plants, Academy of Medicine, 60 623 Poznań, Poland
c Department of Crystallography, Faculty of Chemistry, A. Mickiewicz University, Poznań, Poland
d Department of Chemistry, University of Wyoming, Laramie, WY 82071, U.S.A.
e Institute of Organic Chemistry, Polish Academy of Sciences, 01 224 Warsaw, Poland


The authors describe in full the elucidation of complete structures of guaianolide and germacranolide lactones, isolated from some species of genera Centaurea L., Chartolepis CASS. and others belonging to subtribe Centaureinae DUMORT. The structures were determined mainly on the basis of detailed analysis of 1H NMR and CD spectra. The structure of linichlorin B (XV) was determined by X-ray diffraction analysis.