Collect. Czech. Chem. Commun. 1994, 59, 683-690

Synthesis and Antiviral Activity of Acyclic Nucleoside Analogues of 6-Methyluracil and 4-Alkylamino-6-methyl-2(1H)-pyrimidinones

Sunita Bhat

Department of Medicinal Chemistry, Central Drug Research Institute, Lucknow-226001, India


Reaction of 2,4-Dimethoxy-6-methylpyrimidine (I) with allyl bromide or benzyl bromide afforded 1-substituted 4-methoxy-6-methyl-2(1H)-pyrimidinone intermediates III, X. Oxidation of the compound III afforded racemic cis diol VI. O-Demethylation and nucleophilic displacement of the intermediates III, VI and X gave 1-substituted 6-methyluracils IV, VII, IX and 1-substituted 4-alkylamino-6-methyl-2(1H)-pyrimidinones V, VIII, XII in good yields. The compounds II - XII were evaluated against Ranikhet disease virus (RDV); compounds Vb, VII, X, XIIb - XIId showed 100, 43, 44, 75, 72 and 100% inhibition, respectively.