Collect. Czech. Chem. Commun. 1994, 59, 2562-2564

Preparation of Some N-Substituted 3-Amino-5-cyano-2-pyrazinecarboxamides

Martin Doležal, Jiří Hartl and Miloš Macháček

Faculty of Pharmacy, Charles University, 501 65 Hradec Králové, Czech Republic


During the course of a search for new antimycotic agents a series of 3-amino-5-cyano-2-pyrazinecarboxamides I - XI have been synthesized. The prepared compounds were tested for their antimycotic activity. The MIC of these in the form of dimethyl sulfoxide solutions was measured against Candida albicans ATCC 44859, Candida tropicalis 156, Candida krusei E28, Candida glabrata 20/I, Trichosporon beigelii 1188, Trichophyton mentagrophytes 445, Aspergillus fumigatus 231, and Absidia corymbifera 272. None of the compounds studied was particularly effective.